WHO TB Strategy out of reach for many endemic countries
By, Bobby John and Tim France, March 24, 2007
On the occasion of World TB Day (Saturday March 24), it is important to recognise that resistance to TB drugs has assumed very serious proportions. New global data on TB, published this week by the World Health Organisation (WHO), highlights weaknesses in many national TB programmes, which raises the potential for widespread TB drug resistance. How did the world reach this precarious state?
A WHO expert would argue that increasing levels of TB drug resistance "reflects a failure to implement the WHO Stop TB Strategy". The strategy hopefully maps out the steps that national TB control programmes need to take.
By all accounts then, national TB programmes are not living up to expectations.
The bacterium that causes tuberculosis (TB), Mycobacterium tuberculosis, is naturally sensitive to antibiotic drugs used to treat the disease.
The accepted truth about how TB drug resistance starts is that it is mostly 'acquired' in individual patients, because of inadequate treatment with TB drugs, which are now at least 40 years old.
Poor patient drug adherence, or the use of too few drugs leads - the story goes - to various forms of drug-resistant TB. Multidrug-resistant TB (MDR-TB) is a specific type that does not respond to the two most powerful anti-TB drugs. Latest estimates are that MDR-TB makes up about
4 per cent of all new and previously treated TB globally. Apparently, the antiquated TB drugs are also failing.
Drug-resistant TB is already geographically widespread, which includes places where TB control programmes have been in place for many years.
But incredibly little is known about just how much TB drug resistance there is outside of capital cities, for example, and even in some entire countries where drug resistance may be common because of historically poor TB control.
No progress can be made if TB clinics are there but patients are not.
Today's standard test for TB relies on a technique (sputum microscopy) invented over a hundred years ago. It provides no information about drug resistance. Apparently TB diagnosis is also failing us.
There seem to be too many weak links. A further litany of vital TB programme components has also been ignored for years, in favour of a single jewel in the TB strategy's crown: directly-observed treatment short course, or DOTS.
In many places, a consistent lack of focus and investment has led to chronically weak TB diagnostic and laboratory services; infrequent and incomplete TB drug resistance surveillance; inadequate management of individual drug resistant TB cases; and paltry TB infection control measures, including in health care settings.
Predictably, many TB-endemic countries have indeed failed to meet the exacting standards of the WHO Stop TB Strategy. Given the circumstances in many countries where TB is rife, what is surprising is that they should be asked to pursue such a pipe dream.
DOTS was supposed to stem TB drug resistance. Because of sloppy and unimaginative implementation, it is evidently failing us. As the full extent of TB drug resistance comes to light, prioritising TB drug delivery above all other areas of TB diagnosis and care looks increasingly like WHO has been building a house, just without foundations. We cannot now claim to be surprised when a decade of overlooking the systemic challenges faced by countries with high incidence of TB brings the entire house down.
Promoting policy frameworks is no replacement for working together to achieve what needs to be done to address TB. The Global Plan to Stop TB, (2006-2015), launched by the Stop TB Partnership just over a year ago, is a road map for such a coordinated action. WHO urgently needs to look beyond 'their' Stop TB Strategy to help promote and coordinate the comprehensive range of actions set out in the plan and to recognise the track record of over 500 global partners who put their name behind it.
When she took office just a few months ago, the new WHO director-general, Margaret Chan, identified the organisation's many partnerships as one of her immediate priorities. "Either the partnerships have to change or we have to change or both of us have to change to be more relevant", she said. "What is important to me is, are we getting the results that matter?"
In the case of controlling TB drug resistance, the answer is an unequivocal 'no'.
-----
**About the Authors:
Dr Bobby John, is the Executive Director of the Center for Sustainable Health & Development, India, and President of Global Health Advocates
(www.ghadvocates.org)
Tim France, PhD is Technical and Policy Adviser at Health & Development Networks (www.hdnet.org), and Chair of the Stop TB Partnership Media and Events Task Force (www.stoptb.org)
On the occasion of World TB Day (Saturday March 24), it is important to recognise that resistance to TB drugs has assumed very serious proportions. New global data on TB, published this week by the World Health Organisation (WHO), highlights weaknesses in many national TB programmes, which raises the potential for widespread TB drug resistance. How did the world reach this precarious state?
A WHO expert would argue that increasing levels of TB drug resistance "reflects a failure to implement the WHO Stop TB Strategy". The strategy hopefully maps out the steps that national TB control programmes need to take.
By all accounts then, national TB programmes are not living up to expectations.
The bacterium that causes tuberculosis (TB), Mycobacterium tuberculosis, is naturally sensitive to antibiotic drugs used to treat the disease.
The accepted truth about how TB drug resistance starts is that it is mostly 'acquired' in individual patients, because of inadequate treatment with TB drugs, which are now at least 40 years old.
Poor patient drug adherence, or the use of too few drugs leads - the story goes - to various forms of drug-resistant TB. Multidrug-resistant TB (MDR-TB) is a specific type that does not respond to the two most powerful anti-TB drugs. Latest estimates are that MDR-TB makes up about
4 per cent of all new and previously treated TB globally. Apparently, the antiquated TB drugs are also failing.
Drug-resistant TB is already geographically widespread, which includes places where TB control programmes have been in place for many years.
But incredibly little is known about just how much TB drug resistance there is outside of capital cities, for example, and even in some entire countries where drug resistance may be common because of historically poor TB control.
No progress can be made if TB clinics are there but patients are not.
Today's standard test for TB relies on a technique (sputum microscopy) invented over a hundred years ago. It provides no information about drug resistance. Apparently TB diagnosis is also failing us.
There seem to be too many weak links. A further litany of vital TB programme components has also been ignored for years, in favour of a single jewel in the TB strategy's crown: directly-observed treatment short course, or DOTS.
In many places, a consistent lack of focus and investment has led to chronically weak TB diagnostic and laboratory services; infrequent and incomplete TB drug resistance surveillance; inadequate management of individual drug resistant TB cases; and paltry TB infection control measures, including in health care settings.
Predictably, many TB-endemic countries have indeed failed to meet the exacting standards of the WHO Stop TB Strategy. Given the circumstances in many countries where TB is rife, what is surprising is that they should be asked to pursue such a pipe dream.
DOTS was supposed to stem TB drug resistance. Because of sloppy and unimaginative implementation, it is evidently failing us. As the full extent of TB drug resistance comes to light, prioritising TB drug delivery above all other areas of TB diagnosis and care looks increasingly like WHO has been building a house, just without foundations. We cannot now claim to be surprised when a decade of overlooking the systemic challenges faced by countries with high incidence of TB brings the entire house down.
Promoting policy frameworks is no replacement for working together to achieve what needs to be done to address TB. The Global Plan to Stop TB, (2006-2015), launched by the Stop TB Partnership just over a year ago, is a road map for such a coordinated action. WHO urgently needs to look beyond 'their' Stop TB Strategy to help promote and coordinate the comprehensive range of actions set out in the plan and to recognise the track record of over 500 global partners who put their name behind it.
When she took office just a few months ago, the new WHO director-general, Margaret Chan, identified the organisation's many partnerships as one of her immediate priorities. "Either the partnerships have to change or we have to change or both of us have to change to be more relevant", she said. "What is important to me is, are we getting the results that matter?"
In the case of controlling TB drug resistance, the answer is an unequivocal 'no'.
-----
**About the Authors:
Dr Bobby John, is the Executive Director of the Center for Sustainable Health & Development, India, and President of Global Health Advocates
(www.ghadvocates.org)
Tim France, PhD is Technical and Policy Adviser at Health & Development Networks (www.hdnet.org), and Chair of the Stop TB Partnership Media and Events Task Force (www.stoptb.org)
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